BIO21's L112 BIOPOLYMER product profile

L112 BIOPOLYMER is available packed in a 30 kg plastic bag packed in fiber drums ; 12 drums on BulkBox pallet

L112 BIOPOLYMER is the CHITOSAN spec L112 blended with active ingredients

A non-digestible polysaccharide derived from the deacetylation (removal of the carbonyl and methyl group) of chitin blended with additional proprietary ingredients.

It is a refined β 1 → 4 linked co-polymers of N-acetyl Glucosamine and D-glucosamine. The product is a soft yellow powder with a mild fish taste and aroma; and is easy to encapsulate / tableting. And the important property is fat Triglyceride binding more than 1000 g/g (our standard test method STM-1510)

BIO21 L112 Biopolymer Packing & Packaging 02
BIO21 L112 Biopolymer Packing & Packaging for loading in container
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L112 BIOPOLYMER

Enhance CHITOSAN derivative for dietary supplement (N-acetyl Glucosamine and D-Glucosamine, L112 specification).  A non-digestible polysaccharide derived from the deacetylation (removal of the carbonyl and methyl group) of chitin blended with additional proprietary ingredients.

It is a refined β 1 → 4 linked co-polymers of N-acetyl Glucosamine and D-glucosamine.  The product is a soft yellow powder with a mild fish taste and aroma; and is easy to encapsulate / tableting. And the important property is fat Triglyceride binding more than 1000 g/g (our standard test method STM-1510)

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How come L112 BIOPOLYMER from

OPTIMIZING CHITOSAN CHARACTERISTICS FOR EFFECTIVE USE IN HUMAN WEIGHT-LOSS REGIMENS STUDY

BULLET: ANTI-OBESE AND HYPOLIPIDEMIC EFFECTS OF CHITOSANS IN RATS

What we have learned that flake squidpen-derived chitosans functioned much better than powdered crab and shrimp chitosan in binding fats; corn oil >> beef oil > olive oil > coconut oil. High-molecular-weight (HMW) squid pen chitosan had the highest fat-binding activity; however, the binding was not proportional to degree of deacetylation (DD). The chitosans preferred binding corn oil to olive oil, coconut oil and beef tallow. It is believed that the squidpen chitosans bound all fats better than crab and shrimp chitosans. Hydrophobic force (e.g. adsorption or van der Waals force) rather than electrical attraction is a fundamental factor in undigested (intact) lipid-binding performance of the chitosans. Hydrochloric acid pH 2.0 solution transformed colloidal chitosans into viscous chitosans, while the chitosans were precipitated in water and bicarbonate pH 8.5 solution. Swelling of the chitosans was unchanged in water and bicarbonate environment as in small intestine. Saying that, chitosans with small swelling index (SI) number will not enlarge intestinal luminal tract and make subjects uncomfortable. Formed fat-chitosan complex would be retained in the lumen shortly and excreted in feces eventually. It was found that CTS28 (MW >500 kD, DD >90%) and CTS31 (MW 125-500 kD, DD >90%) chitosans were very large and most effective in binding corn oil and beef tallow. Unfortunately, CTS10 chitosan showed the lowest fat-binding activity. Although they were administered per oral (po) and hydrolyzed partially in the stomach, residual chitosans matrices would retain the fat-binding property in small intestine. Nonetheless, we have not known what affinity of the chitosans for binding digested as well as pre-cooked fats is when compared to the intact (undigested) fats in our current study. Therefore, the chitosans are tested for their binding with pre-cooked fats in vitro. The selected chitosans are also examined for their weight-losing and hypolipidemic effects in prefatten as well as fattening rats. Change of plasma lipid profiles and body weight, liver function and kidney function are monitored in the treated rats.

OBJECTIVES OF THE STUDY

To investigate binding activity of selected chitosans with pre-cooked oils in vitro

To examine weight-losing activity of the chitosans in obese rats

To study effect of the chitosans on plasma lipid profiles in the treated rats

To monitor effect of the chitosans on liver and kidney functions

How come L112 BIOPOLYMER from

CHITOSAN SPEC L112 CHARACTERISTICS

STUDY: CHITOSANS OF INTEREST

Chitosan, a polyglucosamine derived from chitin by deacetylating chitin molecule. It is a cellulose-like polymer located mainly in exoskeletons of arthropods (e.g. crabs, shrimps, lobsters and insects) and squidpen. Chemically and physiologically, the compound can be defined as a dietary polysaccharide fiber which cannot be hydrolyzed by digestive enzymes of humans. The ability of chitosan, a glucosamine polymer formed by deacetylating chitin, is known to interact with hydrophobic compounds such as cholesterol, triglycerides, fatty and bile acids and reduce their absorption or reentry into the mucosal cells of animals and man. Part of this property is likely related to the positive charge of the amide group at pH’s less than 6.5 and its ability to be dissolved at low pH and form a viscous gel at higher pH’s. Chitosan’s capacity to bind bile acids, which consequently reduces the enterohepatic recycling, provides a favorable means of reducing plasma cholesterol. In addition, chitosan forms complex salts that bind to or associate with the triglycerides, fatty acids and other sterol compounds. By means of ionic binding or other associations such as entrapment of hydrophobic compounds, clear evidence indicates that measurable reduction of fat absorption occurs with chitosan feeding. This physiological property to reduce fat absorption has been tested in animal models, clinical studies and the physical properties of fat-binding interactions have also been supported through in vitro laboratory studies. It has exhibited a potent hypocholesterolaemic activity in rats. However, its hypocholesterolaemic mechanism is still unclear. Under different reaction conditions, chitosans with different physicochemical properties can be prepared. Degree of deacetylation (DD) and molecular weight (MW) of chitosan are two important characteristics which greatly affect its chemical and physiological five properties. chitosan is the only abundant cationic polymer having an amino group in its chemical structure and the DD is a characteristic greatly different from those of other dietary fibers. Higher DD reflects more free amino groups in the chitosan molecule and more positive charge in chitosan solution. A previous study showed that the hypocholesterolemic activity of chitosan was better when DD was high (90%deacetylated), which might be due to the electrostatic force between chitosan and anion substances (such as unesterified fatty acid and bile acid) and also cholesterol. MW and size of chitosan is proportional to its viscosity. Entrapment caused by a viscous chitosan would reduce the absorption of fat and cholesterol in diet. Possibly, weight-lowering and hypocholesterolemic mechanisms would be similar to that of certain dietary fibers, guar gum and pectin. Nevertheless, the relationship between the MW of chitosan and its hypocholesterolemic effect is still controversy and under discussion. a recent study has shown that binding capacities of chitosans with bile acids and triglycerides had no correlation with DD in vitro. Essentially, the chitosan has been promoted as an effective, natural nutraceutical to reduce absorption of dietary fat and cholesterol, eventually leading to reduce body weight and blood cholesterol. Our investigations of the chitosans with different positive charges and molecular size will be beneficial in prevention of obesity and cardiovascular disease.

OBJECTIVES

The study was performed in vitro to investigate fat-binding capacity of the chitosans having different molecular size and degree of deacetylation. Cholesterol and bile acid-binding activity of the chitosans were also included. Penetration of the chitosans into intestinal epithelial cells was assayed in vitro.